Eosinophils in infection and intestinal immunity

SP Hogan, A Waddell… - Current opinion in …, 2013 - journals.lww.com
SP Hogan, A Waddell, PC Fulkerson
Current opinion in gastroenterology, 2013journals.lww.com
We describe the clinical evidence of eosinophil involvement in IBD, summarize the in-vitro
and in-vivo evidence of eosinophil antibacterial activity and the biology of eosinophils
focusing on eosinophil-mediated bactericidal mechanisms and the involvement of
eosinophil-derived granule proteins in this response, and conceptualize the contribution of
eosinophils to a response against commensal bacteria in IBD.
Summary
We describe the clinical evidence of eosinophil involvement in IBD, summarize the in-vitro and in-vivo evidence of eosinophil antibacterial activity and the biology of eosinophils focusing on eosinophil-mediated bactericidal mechanisms and the involvement of eosinophil-derived granule proteins in this response, and conceptualize the contribution of eosinophils to a response against commensal bacteria in IBD.
Lippincott Williams & Wilkins