Construction and evaluation of the immune protection of a recombinant divalent protein composed of the MrpA from MR/P fimbriae and flagellin of Proteus mirabilis …
Urinary tract infections (UTI) caused by Proteus mirabilis are prevalent among the
catheterized patients. There is no effective vaccine to reduce the frequency of UTIs caused
by P. mirabilis. In the present study, the immune responses and effectiveness of different
combinations of MrpA and flagellin (FliC) of P. mirabilis were assessed intranasally in the
mice model. The addition of FliC as adjuvant to MrpA in fusion form significantly raised the
mucosal IgA and cellular (IFN-γ and IL-17) responses and maintained the serum IgG …
catheterized patients. There is no effective vaccine to reduce the frequency of UTIs caused
by P. mirabilis. In the present study, the immune responses and effectiveness of different
combinations of MrpA and flagellin (FliC) of P. mirabilis were assessed intranasally in the
mice model. The addition of FliC as adjuvant to MrpA in fusion form significantly raised the
mucosal IgA and cellular (IFN-γ and IL-17) responses and maintained the serum IgG …