Urinary tract infection in a small animal model: transurethral catheterization of male and female mice
AZ Scharff, ML Albert, MA Ingersoll - JoVE (Journal of Visualized …, 2017 - jove.com
Urinary tract infections (UTI) are extremely common worldwide, incurring significant
morbidity and healthcare-associated expenses. Small animal models, which accurately
reflect disease establishment and progression, permit dissection of host-pathogen
interactions and generation of immunity to infection. In mice, intravesical instillation of
uropathogenic E. coli, the causative agent in more than 85% of community acquired UTI,
recapitulates many of the stages of infection observed in humans. Until recently, however …
morbidity and healthcare-associated expenses. Small animal models, which accurately
reflect disease establishment and progression, permit dissection of host-pathogen
interactions and generation of immunity to infection. In mice, intravesical instillation of
uropathogenic E. coli, the causative agent in more than 85% of community acquired UTI,
recapitulates many of the stages of infection observed in humans. Until recently, however …