Excessive proteolytic activity is a feature of chronic wounds such as venous ulcers, in which
resolution of the inflammatory response fails and restorative matrix accumulation is delayed
as a consequence. The inflammatory actions of native androgens during the healing of
acute skin wounds have lately been characterized. We have now investigated the
hypothesis that such activities may impact upon the balance between anabolic and catabolic
processes during wound healing. We report that wound deposition of both type I collagen …