Opposing roles of dendritic cell subsets in experimental GN
S Brähler, BH Zinselmeyer, S Raju… - Journal of the …, 2018 - journals.lww.com
Dendritic cells (DCs) are thought to form a dendritic network across barrier surfaces and
throughout organs, including the kidney, to perform an important sentinel function. However,
previous studies of DC function used markers, such as CD11c or CX3CR1, that are not
unique to DCs. Here, we evaluated the role of DCs in renal inflammation using a CD11c
reporter mouse line and two mouse lines with DC-specific reporters, Zbtb46-GFP and Snx22-
GFP. Multiphoton microscopy of kidney sections confirmed that most of the dendritically …
throughout organs, including the kidney, to perform an important sentinel function. However,
previous studies of DC function used markers, such as CD11c or CX3CR1, that are not
unique to DCs. Here, we evaluated the role of DCs in renal inflammation using a CD11c
reporter mouse line and two mouse lines with DC-specific reporters, Zbtb46-GFP and Snx22-
GFP. Multiphoton microscopy of kidney sections confirmed that most of the dendritically …