Survivin mediates renal proximal tubule recovery from AKI
J Chen, JK Chen, EM Conway… - Journal of the American …, 2013 - journals.lww.com
AKI induces the renoprotective upregulation of survivin expression in kidney epithelial cells,
but the underlying mechanisms have not been identified. To determine the role of survivin in
renal recovery from AKI, we generated mice with renal proximal tubule-specific deletion of
survivin (survivin ptKO). Renal survivin expression increased substantially in response to
ischemia-reperfusion (I/R) injury in control littermates but remained minimal in survivin ptKO
mice. Functional and histologic data indicated similar degrees of renal injury in survivin ptKO …
but the underlying mechanisms have not been identified. To determine the role of survivin in
renal recovery from AKI, we generated mice with renal proximal tubule-specific deletion of
survivin (survivin ptKO). Renal survivin expression increased substantially in response to
ischemia-reperfusion (I/R) injury in control littermates but remained minimal in survivin ptKO
mice. Functional and histologic data indicated similar degrees of renal injury in survivin ptKO …