[HTML][HTML] Evaluation of molecular profiles in calcineurin inhibitor toxicity post–kidney transplant: input to chronic allograft dysfunction
DG Maluf, CI Dumur, JL Suh, JK Lee, HP Cathro… - American Journal of …, 2014 - Elsevier
The molecular basis of calcineurin inhibitor toxicity (CNIT) in kidney transplantation (KT) and
its contribution to chronic allograft dysfunction (CAD) with interstitial fibrosis (IF) and tubular
atrophy (TA) were evaluated by:(1) identifying specific CNIT molecular pathways that
associate with allograft injury (cross-sectional study) and (2) assessing the contribution of
the identified CNIT signature in the progression to CAD with IF/TA (longitudinal study).
Kidney biopsies from well-selected transplant recipients with histological diagnosis of CNIT …
its contribution to chronic allograft dysfunction (CAD) with interstitial fibrosis (IF) and tubular
atrophy (TA) were evaluated by:(1) identifying specific CNIT molecular pathways that
associate with allograft injury (cross-sectional study) and (2) assessing the contribution of
the identified CNIT signature in the progression to CAD with IF/TA (longitudinal study).
Kidney biopsies from well-selected transplant recipients with histological diagnosis of CNIT …
