Unravelling the pathogenesis of myasthenia gravis

A Vincent - Nature Reviews Immunology, 2002 - nature.com
Nature Reviews Immunology, 2002nature.com
Myasthenia gravis is a relatively rare neurological disease that is associated with loss of the
acetylcholine receptors that initiate muscle contraction. This results in muscle weakness,
which can be life-threatening. The story of how both the physiological basis of the disease
and the role of acetylcholine-receptor-specific antibodies were determined is a classic
example of the application of basic science to clinical medicine, and it has provided a model
for defining other antibody-mediated disorders of the peripheral and central nervous …
Abstract
Myasthenia gravis is a relatively rare neurological disease that is associated with loss of the acetylcholine receptors that initiate muscle contraction. This results in muscle weakness, which can be life-threatening. The story of how both the physiological basis of the disease and the role of acetylcholine-receptor-specific antibodies were determined is a classic example of the application of basic science to clinical medicine, and it has provided a model for defining other antibody-mediated disorders of the peripheral and central nervous systems.
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