[HTML][HTML] Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: efficient intestinal bile salt absorption in the absence of ileal bile acid-binding …
T Kok, CV Hulzebos, H Wolters, R Havinga… - Journal of Biological …, 2003 - ASBMB
The bile salt-activated farnesoid X receptor (FXR; NR1H4) controls expression of several
genes considered crucial in maintenance of bile salt homeostasis. We evaluated the
physiological consequences of FXR deficiency on bile formation and on the kinetics of the
enterohepatic circulation of cholate, the major bile salt species in mice. The pool size,
fractional turnover rate, synthesis rate, and intestinal absorption of cholate were determined
by stable isotope dilution and were related to expression of relevant transporters in the livers …
genes considered crucial in maintenance of bile salt homeostasis. We evaluated the
physiological consequences of FXR deficiency on bile formation and on the kinetics of the
enterohepatic circulation of cholate, the major bile salt species in mice. The pool size,
fractional turnover rate, synthesis rate, and intestinal absorption of cholate were determined
by stable isotope dilution and were related to expression of relevant transporters in the livers …