[HTML][HTML] Overexpression of secretory phospholipase A2 causes rapid catabolism and altered tissue uptake of high density lipoprotein cholesteryl ester and …
UJF Tietge, C Maugeais, W Cain, D Grass… - Journal of Biological …, 2000 - ASBMB
Plasma levels of high density lipoprotein (HDL) cholesterol and its major protein component
apolipoprotein (apo) AI are significantly reduced in both acute and chronic inflammatory
conditions, but the basis for this phenomenon is not well understood. We hypothesized that
secretory phospholipase A 2 (sPLA 2), an acute phase protein that has been found in
association with HDL, promotes HDL catabolism. A series of HDL metabolic studies were
performed in transgenic mice that specifically overexpress human sPLA 2 but have no …
apolipoprotein (apo) AI are significantly reduced in both acute and chronic inflammatory
conditions, but the basis for this phenomenon is not well understood. We hypothesized that
secretory phospholipase A 2 (sPLA 2), an acute phase protein that has been found in
association with HDL, promotes HDL catabolism. A series of HDL metabolic studies were
performed in transgenic mice that specifically overexpress human sPLA 2 but have no …