[HTML][HTML] High density lipoprotein (HDL) particle uptake mediated by scavenger receptor class B type 1 results in selective sorting of HDL cholesterol from protein and …
High density lipoprotein (HDL) mediates reverse transport of cholesterol from atheroma
foam cells to the liver, but the mechanisms of hepatic uptake and trafficking of HDL particles
are poorly understood. In contrast to its accepted role as a cell surface receptor, scavenger
receptor class B type 1 (SR-BI) is shown to be an endocytic receptor that mediates HDL
particle uptake and recycling, but not degradation, in both transfected Chinese hamster
ovary cells and hepatocytes. Confocal microscopy of polarized primary hepatocytes shows …
foam cells to the liver, but the mechanisms of hepatic uptake and trafficking of HDL particles
are poorly understood. In contrast to its accepted role as a cell surface receptor, scavenger
receptor class B type 1 (SR-BI) is shown to be an endocytic receptor that mediates HDL
particle uptake and recycling, but not degradation, in both transfected Chinese hamster
ovary cells and hepatocytes. Confocal microscopy of polarized primary hepatocytes shows …