[HTML][HTML] PCSK9: a convertase that coordinates LDL catabolism
JD Horton, JC Cohen, HH Hobbs - Journal of lipid research, 2009 - ASBMB
The identification and characterization of proprotein convertase subtilisin-like/kexin type 9
(PCSK9) have provided new insights into LDL metabolism and the causal role of LDL in
coronary heart disease (CHD). PCSK9 is a secreted protease that mediates degradation of
the LDL receptor by interacting with the extracellular domain and targeting the receptor for
degradation. Individuals with loss-of-function mutations in PCSK9 have reduced plasma
levels of LDL cholesterol and are protected from CHD; these observations have validated …
(PCSK9) have provided new insights into LDL metabolism and the causal role of LDL in
coronary heart disease (CHD). PCSK9 is a secreted protease that mediates degradation of
the LDL receptor by interacting with the extracellular domain and targeting the receptor for
degradation. Individuals with loss-of-function mutations in PCSK9 have reduced plasma
levels of LDL cholesterol and are protected from CHD; these observations have validated …