Dietary carbohydrate restriction induces a unique metabolic state positively affecting atherogenic dyslipidemia, fatty acid partitioning, and metabolic syndrome
JS Volek, ML Fernandez, RD Feinman… - Progress in lipid …, 2008 - Elsevier
Abnormal fatty acid metabolism and dyslipidemia play an intimate role in the pathogenesis
of metabolic syndrome and cardiovascular diseases. The availability of glucose and insulin
predominate as upstream regulatory elements that operate through a collection of
transcription factors to partition lipids toward anabolic pathways. The unraveling of the
details of these cellular events has proceeded rapidly, but their physiologic relevance to
lifestyle modification has been largely ignored. Here we highlight the role of dietary input …
of metabolic syndrome and cardiovascular diseases. The availability of glucose and insulin
predominate as upstream regulatory elements that operate through a collection of
transcription factors to partition lipids toward anabolic pathways. The unraveling of the
details of these cellular events has proceeded rapidly, but their physiologic relevance to
lifestyle modification has been largely ignored. Here we highlight the role of dietary input …