15-Deoxy-Δ12, 14-prostaglandin J2 induces expression of 15-hydroxyprostaglandin dehydrogenase through Elk-1 activation in human breast cancer MDA-MB-231 …
HR Kim, HN Lee, K Lim, YJ Surh, HK Na - Mutation Research/Fundamental …, 2014 - Elsevier
Overproduction of prostaglandin E 2 (PGE 2) has been reported to be implicated in
carcinogenesis. The intracellular level of PGE 2 is maintained not only by its biosynthesis,
but also by inactivation/degradation. 15-Hydroxyprostaglandin dehydrogenase (15-PGDH)
is the key enzyme that catalyzes the conversion of oncogenic PGE 2 to a biologically
inactive keto metabolite. In the present study, we demonstrate that 15-deoxy-Δ 12, 14-
prostaglandin J 2 (15d-PGJ 2), one of the terminal products of cyclooxygenase-2 …
carcinogenesis. The intracellular level of PGE 2 is maintained not only by its biosynthesis,
but also by inactivation/degradation. 15-Hydroxyprostaglandin dehydrogenase (15-PGDH)
is the key enzyme that catalyzes the conversion of oncogenic PGE 2 to a biologically
inactive keto metabolite. In the present study, we demonstrate that 15-deoxy-Δ 12, 14-
prostaglandin J 2 (15d-PGJ 2), one of the terminal products of cyclooxygenase-2 …