[HTML][HTML] Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked …
C Mao, M Zhou, FM Uckun - Journal of Biological Chemistry, 2001 - ASBMB
Bruton's tyrosine kinase is intimately involved in signal transduction pathways regulating
survival, activation, proliferation, and differentiation of B lineage lymphoid cells. Mutations in
the human btk gene are the cause of X-linked agammaglobulinemia, a male immune
deficiency disorder characterized by a lack of mature, immunoglobulin-producing B
lymphocytes. We have determined the x-ray crystal structure of the Bruton's tyrosine kinase
kinase domain in its unphosphorylated state to a 2.1 Å resolution. A comparison with the …
survival, activation, proliferation, and differentiation of B lineage lymphoid cells. Mutations in
the human btk gene are the cause of X-linked agammaglobulinemia, a male immune
deficiency disorder characterized by a lack of mature, immunoglobulin-producing B
lymphocytes. We have determined the x-ray crystal structure of the Bruton's tyrosine kinase
kinase domain in its unphosphorylated state to a 2.1 Å resolution. A comparison with the …