Mitochondrial toxicity of antiviral drugs
W Lewis, MC Dalakas - Nature medicine, 1995 - nature.com
W Lewis, MC Dalakas
Nature medicine, 1995•nature.comLong-term treatment with antiviral nucleoside analogue drugs, such as AZT, can give rise to
delayed and at times severe mitochondrial toxicity. Although these toxic effects are manifest
in many tissues, a common disease mechanism can explain the diverse clinical events. A
better understanding of these disorders will shed light on genetic mitochondrial diseases
and lead to the design of safer and more effective antiviral drugs.
delayed and at times severe mitochondrial toxicity. Although these toxic effects are manifest
in many tissues, a common disease mechanism can explain the diverse clinical events. A
better understanding of these disorders will shed light on genetic mitochondrial diseases
and lead to the design of safer and more effective antiviral drugs.
Abstract
Long-term treatment with antiviral nucleoside analogue drugs, such as AZT, can give rise to delayed and at times severe mitochondrial toxicity. Although these toxic effects are manifest in many tissues, a common disease mechanism can explain the diverse clinical events. A better understanding of these disorders will shed light on genetic mitochondrial diseases and lead to the design of safer and more effective antiviral drugs.
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