Regulated gene expression by transcription factor networks is critical for normal kidney
function. Disruption of these complex networks leads to biochemical aberrations associated
with many renal diseases. Epigenetic mechanisms not involving changes in DNA sequence,
such as DNA methylation and post-translational modifications of nucleosomal histones, also
play a critical role in gene regulation by modulating chromatin access to the cellular
machinery for transcription. These epigenetic modifications can be affected by intrinsic and …