Methylglyoxal metabolism and diabetic complications: roles of aldose reductase, glyoxalase-I, betaine aldehyde dehydrogenase and 2-oxoaldehyde dehydrogenase

DL Vander Jagt, LA Hunsaker - Chemico-biological interactions, 2003 - Elsevier
The 2-oxoaldehyde methylglyoxal (MeG) is the precursor to a number of the known
advanced glycation endproducts (AGE) implicated in the development of diabetic
complications. Other 2-oxoaldehydes that are important in AGE formation, such as glyoxal,
glucosone, deoxyglucosone, xylosone and deoxyxylosone, are produced by nonenzymatic
reactions. By contrast, MeG is produced by both enzymatic and nonenzymatic processes,
most of which appear to be enhanced in diabetes. MeG may be a major precursor to …