The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life.

PJ Thornalley - Biochemical Journal, 1990 - ncbi.nlm.nih.gov
PJ Thornalley
Biochemical Journal, 1990ncbi.nlm.nih.gov
INTRODUCTION The glyoxalase system catalyses the conversion of methylglyoxal to D-
lactic acid via the intermediate SD-lactoylglutathione (Fig. 1). It comprises two enzymes,
glyoxalase I and glyoxalase II, and a catalytic amount of reduced glutathione (Carrington &
Douglas, 1986; Thornalley, 1989). Glyoxalase I (EC 4.4. 1.5, lactoylglutathione lyase)
catalyses the formation of SD-lactoylglutathione from the hemithioacetal formed non-
enzymically from methylglyoxal and reduced glutathione (Mannervik, 1980; Sellin et al …
INTRODUCTION The glyoxalase system catalyses the conversion of methylglyoxal to D-lactic acid via the intermediate SD-lactoylglutathione (Fig. 1). It comprises two enzymes, glyoxalase I and glyoxalase II, and a catalytic amount of reduced glutathione (Carrington & Douglas, 1986; Thornalley, 1989). Glyoxalase I (EC 4.4. 1.5, lactoylglutathione lyase) catalyses the formation of SD-lactoylglutathione from the hemithioacetal formed non-enzymically from methylglyoxal and reduced glutathione (Mannervik, 1980; Sellin et al., 1983):
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