Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems-role in ageing and disease
PJ Thornalley - Drug metabolism and drug interactions, 2008 - degruyter.com
PJ Thornalley
Drug metabolism and drug interactions, 2008•degruyter.comGlycation of proteins, nucleotides and basic phospholipids by glyoxal and methylglyoxal-
physiological substrates of glyoxalase 1-iso potentially damaging to the proteome, genome
and lipidome. Glyoxalase 1 suppresses glycation by these α-oxoaldehyde metabolites and
thereby represents part of the enzymatic defence against glycation. Albert Szent-Györgyi
pioneered and struggled to understand the physiological function of methylglyoxal and the
glyoxalase system. We now appreciate that glyoxalase 1 protects against dicarbonyl …
physiological substrates of glyoxalase 1-iso potentially damaging to the proteome, genome
and lipidome. Glyoxalase 1 suppresses glycation by these α-oxoaldehyde metabolites and
thereby represents part of the enzymatic defence against glycation. Albert Szent-Györgyi
pioneered and struggled to understand the physiological function of methylglyoxal and the
glyoxalase system. We now appreciate that glyoxalase 1 protects against dicarbonyl …
Summary
Glycation of proteins, nucleotides and basic phospholipids by glyoxal and methylglyoxal-physiological substrates of glyoxalase 1-iso potentially damaging to the proteome, genome and lipidome. Glyoxalase 1 suppresses glycation by these α-oxoaldehyde metabolites and thereby represents part of the enzymatic defence against glycation. Albert Szent-Györgyi pioneered and struggled to understand the physiological function of methylglyoxal and the glyoxalase system. We now appreciate that glyoxalase 1 protects against dicarbonyl modifications of the proteome, genome and lipome. Latest research suggests there are functional modifications of this process-implying a role in cell signalling, ageing and disease.
De Gruyter