[HTML][HTML] Mechanistic sharing between NK cells in ABMR and effector T cells in TCMR
Human organ allograft rejection depends on effector lymphocytes: NK cells in antibody-
mediated rejection (ABMR) and effector T cells in T cell-mediated rejection (TCMR). We
hypothesized that NK cell CD16a stimulation and CD8 T cell TCR/CD3 stimulation represent
highly similar effector systems, and should lead to shared molecular changes between
ABMR and TCMR. We studied similarity between soluble proteins and the transcripts
induced in CD16a stimulated NK cells and TCR/CD3-stimulated T cells in vitro. Of 30 …
mediated rejection (ABMR) and effector T cells in T cell-mediated rejection (TCMR). We
hypothesized that NK cell CD16a stimulation and CD8 T cell TCR/CD3 stimulation represent
highly similar effector systems, and should lead to shared molecular changes between
ABMR and TCMR. We studied similarity between soluble proteins and the transcripts
induced in CD16a stimulated NK cells and TCR/CD3-stimulated T cells in vitro. Of 30 …