[HTML][HTML] Pretransplant donor-specific HLA class-I and-II antibodies are associated with an increased risk for kidney graft failure
HG Otten, MC Verhaar, HPE Borst, RJ Hené… - American journal of …, 2012 - Elsevier
Pretransplant risk assessment of graft failure is important for donor selection and choice of
immunosuppressive treatment. We examined the relation between kidney graft failure and
presence of IgG donor specific HLA antibodies (DSA) or C1q-fixing DSA, detected by single
antigen bead array (SAB) in pretransplant sera from 837 transplantations. IgG-DSA were
found in 290 (35%) sera, whereas only 30 (4%) sera had C1q-fixing DSA. Patients with both
class-I plus-II DSA had a 10 yr graft survival of 30% versus 72% in patients without HLA …
immunosuppressive treatment. We examined the relation between kidney graft failure and
presence of IgG donor specific HLA antibodies (DSA) or C1q-fixing DSA, detected by single
antigen bead array (SAB) in pretransplant sera from 837 transplantations. IgG-DSA were
found in 290 (35%) sera, whereas only 30 (4%) sera had C1q-fixing DSA. Patients with both
class-I plus-II DSA had a 10 yr graft survival of 30% versus 72% in patients without HLA …