APOL1-G0 or APOL1-G2 transgenic models develop preeclampsia but not kidney disease

LA Bruggeman, Z Wu, L Luo… - Journal of the …, 2016 - journals.lww.com
APOL1 risk variants are associated with kidney disease in blacks, but the mechanisms of
renal injury associated with APOL1 risk variants are unknown. Because APOL1 is unique to
humans and some primates, we created transgenic (Tg) mice using the promoter of nephrin-
encoding Nphs1 to express the APOL1 reference sequence (G0) or the G2 risk variant in
podocytes, establishing Tg lines with a spectrum of APOL1 expression levels. Podocytes
from Tg-G0 and Tg-G2 mice did not undergo necrosis, apoptosis, or autophagic cell death in …