Two coding sequence variants in the APOL1 gene (G1 and G2) explain much of the
increased risk for FSGS, HIV-associated nephropathy, and hypertension-attributed ESRD
among people of recent African ancestry. The ApoL1 protein is expressed in a wide variety
of cell tissues. It has been assumed that the majority of circulating ApoL1 is produced by the
liver, but this has not been shown. Using mass spectrometry, we genotyped and quantified
the circulating ApoL1 in two liver transplant recipients whose native APOL1 genotype …