[HTML][HTML] Activation of Ca2+/Calmodulin-dependent Protein Kinase (CaM-kinase) IV by CaM-kinase Kinase in Jurkat T Lymphocytes (∗)
IK Park, TR Soderling - Journal of Biological Chemistry, 1995 - ASBMB
Ca 2+/calmodulin-dependent protein kinase IV (CaM-kinase IV), a member of the CaM-
kinase family involved in transcriptional regulation, is stimulated by Ca 2+/CaM but also
requires phosphorylation by a CaM-kinase kinase for full activation. In this study we
investigated the physiological role of a CaM-kinase cascade in Jurkat T human lymphocytes
through antigen receptor (CD3) signaling. Total and Ca 2+-independent CaM-kinase IV
activities were increased 8-14-fold by anti-CD3 antibody. This CD3-mediated activation …
kinase family involved in transcriptional regulation, is stimulated by Ca 2+/CaM but also
requires phosphorylation by a CaM-kinase kinase for full activation. In this study we
investigated the physiological role of a CaM-kinase cascade in Jurkat T human lymphocytes
through antigen receptor (CD3) signaling. Total and Ca 2+-independent CaM-kinase IV
activities were increased 8-14-fold by anti-CD3 antibody. This CD3-mediated activation …