Epigenetic modifications in fibrotic diseases: implications for pathogenesis and pharmacological targets
HW Yao, J Li - The Journal of pharmacology and experimental …, 2015 - Elsevier
Organ fibrosis is a complex and chronic disorder that results from a variety of acute injuries
and contributes to thirty percent of naturally occurring deaths worldwide. The main feature of
organ fibrosis is the excessive accumulation and deposit of extracellular matrix, thereby
leading to organ dysfunction, loss of elasticity, and development of a rigid organ.
Accumulating evidence shows that epigenetic remodeling, including aberrant DNA
methylation and noncoding RNA expression as well as histone post-translational …
and contributes to thirty percent of naturally occurring deaths worldwide. The main feature of
organ fibrosis is the excessive accumulation and deposit of extracellular matrix, thereby
leading to organ dysfunction, loss of elasticity, and development of a rigid organ.
Accumulating evidence shows that epigenetic remodeling, including aberrant DNA
methylation and noncoding RNA expression as well as histone post-translational …
