[PDF][PDF] Lamina-associated domains: links with chromosome architecture, heterochromatin, and gene repression
B Van Steensel, AS Belmont - Cell, 2017 - cell.com
Cell, 2017•cell.com
In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the
nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize
chromosomes inside the nucleus and have been associated with gene repression. Here, we
discuss the properties of LADs, the molecular mechanisms that determine their association
with the nuclear lamina, their dynamic links with other nuclear compartments, and their
proposed roles in gene regulation.
nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize
chromosomes inside the nucleus and have been associated with gene repression. Here, we
discuss the properties of LADs, the molecular mechanisms that determine their association
with the nuclear lamina, their dynamic links with other nuclear compartments, and their
proposed roles in gene regulation.
In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize chromosomes inside the nucleus and have been associated with gene repression. Here, we discuss the properties of LADs, the molecular mechanisms that determine their association with the nuclear lamina, their dynamic links with other nuclear compartments, and their proposed roles in gene regulation.
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