Fibrotic lung fibroblasts show blunted inhibition by cAMP due to deficient cAMP response element-binding protein phosphorylation
X Liu, SQ Sun, RS Ostrom - The Journal of pharmacology and experimental …, 2005 - Elsevier
Pulmonary fibroblasts regulate extracellular matrix production and degradation; thus, they
are critical for maintenance of lung structure, function, and repair. In pulmonary fibrosis,
fibroblasts produce excess collagen and form fibrotic foci that eventually impair lung
function, but the mechanisms responsible for these alterations are not known. Receptors
coupled to the stimulation of cAMP production can inhibit activation of fibroblasts and
thereby are antifibrotic. To test whether this signaling pathway is altered in pulmonary …
are critical for maintenance of lung structure, function, and repair. In pulmonary fibrosis,
fibroblasts produce excess collagen and form fibrotic foci that eventually impair lung
function, but the mechanisms responsible for these alterations are not known. Receptors
coupled to the stimulation of cAMP production can inhibit activation of fibroblasts and
thereby are antifibrotic. To test whether this signaling pathway is altered in pulmonary …
