Altered production and regulation of monocyte chemoattractant protein-1 from pulmonary fibroblasts isolated from patients with idiopathic pulmonary fibrosis
TJ Standiford, MR Rolfe, SL Kunkel, JP Lynch… - Chest, 1993 - journal.chestnet.org
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48109 pression or regulation. Untreated PF from" normal" patients produced minimal
amounts of MCP-l (1.89 nglml). In contrast, PF from IPF patients constitutively expressed
15.3 nglml of MCF-l, representing an 8-fold increase over normal PF. While IPF and normal
PF produced similar quantities of MCF-I in response to ILl, differences in the regulation of
MCF-l production from the two cell populations were observed. Concomitant treatment of ILl …
48109 pression or regulation. Untreated PF from" normal" patients produced minimal
amounts of MCP-l (1.89 nglml). In contrast, PF from IPF patients constitutively expressed
15.3 nglml of MCF-l, representing an 8-fold increase over normal PF. While IPF and normal
PF produced similar quantities of MCF-I in response to ILl, differences in the regulation of
MCF-l production from the two cell populations were observed. Concomitant treatment of ILl …