BET bromodomain proteins mediate downstream signaling events following growth factor stimulation in human lung fibroblasts and are involved in bleomycin-induced …
X Tang, R Peng, Y Ren, S Apparsundaram… - Molecular …, 2013 - Elsevier
Epigenetic alterations, such as histone acetylation, regulate the signaling outcomes and
phenotypic responses of fibroblasts after growth factor stimulation. The bromodomain and
extra-terminal domain–containing proteins (Brd) bind to acetylated histone residues,
resulting in recruitment of components of the transcriptional machinery and subsequent
gene transcription. Given the central importance of fibroblasts in tissue fibrosis, this study
sought to determine the role of Brd proteins in human lung fibroblasts (LFs) after growth …
phenotypic responses of fibroblasts after growth factor stimulation. The bromodomain and
extra-terminal domain–containing proteins (Brd) bind to acetylated histone residues,
resulting in recruitment of components of the transcriptional machinery and subsequent
gene transcription. Given the central importance of fibroblasts in tissue fibrosis, this study
sought to determine the role of Brd proteins in human lung fibroblasts (LFs) after growth …
