Ketone bodies as fuel in heart failure
K Huynh - Nature Reviews Cardiology, 2016 - nature.com
K Huynh
Nature Reviews Cardiology, 2016•nature.comHeart failure is characterized by changes in myocardial fuel metabolism and bioenergetics,
and the heart shifts from utilizing fatty acids as its main fuel source to more oxygen-sparing
carbohydrate metabolism. Two studies published in Circulation now show that ketone
utilization is increased in both animal models of heart failure and the human failing
heart.Numerous studies using animal models of heart disease have demonstrated that the
failing heart shifts from fatty acid oxidation (FAO) to increased reliance on glycolysis for …
and the heart shifts from utilizing fatty acids as its main fuel source to more oxygen-sparing
carbohydrate metabolism. Two studies published in Circulation now show that ketone
utilization is increased in both animal models of heart failure and the human failing
heart.Numerous studies using animal models of heart disease have demonstrated that the
failing heart shifts from fatty acid oxidation (FAO) to increased reliance on glycolysis for …
Heart failure is characterized by changes in myocardial fuel metabolism and bioenergetics, and the heart shifts from utilizing fatty acids as its main fuel source to more oxygen-sparing carbohydrate metabolism. Two studies published in Circulation now show that ketone utilization is increased in both animal models of heart failure and the human failing heart.
Numerous studies using animal models of heart disease have demonstrated that the failing heart shifts from fatty acid oxidation (FAO) to increased reliance on glycolysis for energy production. The pathways through which the heart compensates for reduced FAO are unknown, and an integrated signature of metabolism in the human nondiabetic failing heart is yet to be defined.
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