Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology
NJ Abbott - Neurochemistry international, 2004 - Elsevier
This review surveys evidence for the flow of brain interstitial fluid (ISF) via preferential
pathways through the brain, and its relation to cerebrospinal fluid (CSF). Studies over> 100
years have raised several controversial points, not all of them resolved. Recent studies have
usefully combined a histological and a mathematical approach. Taken together the evidence
indicates an ISF bulk flow rate of 0.1–0.3 μlmin− 1g− 1 in rat brain along preferential
pathways especially perivascular spaces and axon tracts. The main source of this fluid is …
pathways through the brain, and its relation to cerebrospinal fluid (CSF). Studies over> 100
years have raised several controversial points, not all of them resolved. Recent studies have
usefully combined a histological and a mathematical approach. Taken together the evidence
indicates an ISF bulk flow rate of 0.1–0.3 μlmin− 1g− 1 in rat brain along preferential
pathways especially perivascular spaces and axon tracts. The main source of this fluid is …