Dedicator of cytokinesis 8 regulates signal transducer and activator of transcription 3 activation and promotes TH17 cell differentiation
S Keles, LM Charbonnier, V Kabaleeswaran… - Journal of Allergy and …, 2016 - Elsevier
Background The autosomal recessive hyper-IgE syndrome (HIES) caused by dedicator of
cytokinesis 8 (DOCK8) deficiency shares clinical features with autosomal dominant HIES
because of signal transducer and activator of transcription 3 (STAT3) mutations, including
recurrent infections and mucocutaneous candidiasis, which are suggestive of TH 17 cell
dysfunction. The mechanisms underlying this phenotypic overlap are unclear. Objective We
sought to elucidate common mechanisms operating in the different forms of HIES. Methods …
cytokinesis 8 (DOCK8) deficiency shares clinical features with autosomal dominant HIES
because of signal transducer and activator of transcription 3 (STAT3) mutations, including
recurrent infections and mucocutaneous candidiasis, which are suggestive of TH 17 cell
dysfunction. The mechanisms underlying this phenotypic overlap are unclear. Objective We
sought to elucidate common mechanisms operating in the different forms of HIES. Methods …