[HTML][HTML] IDH1 gene transcription is sterol regulated and activated by SREBP-1a and SREBP-2 in human hepatoma HepG2 cells: evidence that IDH1 may regulate …
I Shechter, P Dai, L Huo, G Guan - Journal of lipid research, 2003 - ASBMB
The mRNA level for cytosolic NADP-dependent isocitrate dehydrogenase (IDH1) increases
2.3-fold, and enzyme activity of NADP-isocitrate dehydrogenase (IDH) 63%, in sterol-
deprived HepG2 cells. The mRNA levels of the NADP-and NAD-dependent mitochondrial
enzymes show limited or lack of regulation under the same conditions. Nucleotide
sequences that are required, and sufficient, for the sterol regulation of transcription are
located within a 67 bp region of an IDH1-secreted alkaline phosphatase promoter-reporter …
2.3-fold, and enzyme activity of NADP-isocitrate dehydrogenase (IDH) 63%, in sterol-
deprived HepG2 cells. The mRNA levels of the NADP-and NAD-dependent mitochondrial
enzymes show limited or lack of regulation under the same conditions. Nucleotide
sequences that are required, and sufficient, for the sterol regulation of transcription are
located within a 67 bp region of an IDH1-secreted alkaline phosphatase promoter-reporter …