Corticosteroid-dependent sodium transport in a novel immortalized mouse collecting duct principal cell line
M BENS, V VALLET… - Journal of the …, 1999 - journals.lww.com
The final control of sodium balance takes place in the cortical collecting duct (CCD) of the
nephron, where corticosteroid hormones regulate sodium reabsorption by acting through
mineralocorticoid (MR) and/or glucocorticoid (GR) receptors. A clone of principal CCD cells
(mpkCCD c14) has been established that is derived from a transgenic mouse (SV40 large T
antigen under the control of the SV40 enhancer/L-type pyruvate kinase promoter). Cells
grown on filters form polarized monolayers with high electrical transepithelial resistance (RT …
nephron, where corticosteroid hormones regulate sodium reabsorption by acting through
mineralocorticoid (MR) and/or glucocorticoid (GR) receptors. A clone of principal CCD cells
(mpkCCD c14) has been established that is derived from a transgenic mouse (SV40 large T
antigen under the control of the SV40 enhancer/L-type pyruvate kinase promoter). Cells
grown on filters form polarized monolayers with high electrical transepithelial resistance (RT …