[HTML][HTML] The in vivo TRPV6 protein starts at a non-AUG triplet, decoded as methionine, upstream of canonical initiation at AUG
C Fecher-Trost, U Wissenbach, A Beck… - Journal of Biological …, 2013 - ASBMB
TRPV6 channels function as epithelial Ca 2+ entry pathways in the epididymis, prostate, and
placenta. However, the identity of the endogenous TRPV6 protein relies on predicted gene
coding regions and is only known to a certain level of approximation. We show that in vivo
the TRPV6 protein has an extended N terminus. Translation initiates at a non-AUG codon, at
ACG, which is decoded by methionine and which is upstream of the annotated AUG, which
is not used for initiation. The in vitro properties of channels formed by the extended full …
placenta. However, the identity of the endogenous TRPV6 protein relies on predicted gene
coding regions and is only known to a certain level of approximation. We show that in vivo
the TRPV6 protein has an extended N terminus. Translation initiates at a non-AUG codon, at
ACG, which is decoded by methionine and which is upstream of the annotated AUG, which
is not used for initiation. The in vitro properties of channels formed by the extended full …