The low PLC-δ1 expression in cystic fibrosis bronchial epithelial cells induces upregulation of TRPV6 channel activity
L Vachel, C Norez, C Jayle, F Becq, C Vandebrouck - Cell Calcium, 2015 - Elsevier
Increase of Ca 2+ influx in Cystic Fibrosis (CF) cells has been reported to be related to
Transient Receptor Potential Canonical (TRPC6) channel, which is implicated in a functional
coupling with Cystic Fibrosis Transmembrane conductance Regulator (CFTR). Several
members of the Transient Receptor Potential Vanilloid (TRPV) channels family have already
been described as emerging target for respiratory diseases. Two specific isoforms, TRPV5
and TRPV6 are of particular interest in the context of CF Ca 2+ homeostasis as they are …
Transient Receptor Potential Canonical (TRPC6) channel, which is implicated in a functional
coupling with Cystic Fibrosis Transmembrane conductance Regulator (CFTR). Several
members of the Transient Receptor Potential Vanilloid (TRPV) channels family have already
been described as emerging target for respiratory diseases. Two specific isoforms, TRPV5
and TRPV6 are of particular interest in the context of CF Ca 2+ homeostasis as they are …