[HTML][HTML] Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption
JB Peng, XZ Chen, UV Berger, PM Vassilev… - Journal of Biological …, 1999 - ASBMB
Calcium is a major component of the mineral phase of bone and serves as a key
intracellular second messenger. Postnatally, all bodily calcium must be absorbed from the
diet through the intestine. Here we report the properties of a calcium transport protein (CaT1)
cloned from rat duodenum using an expression cloning strategy in Xenopus laevis oocytes,
which likely plays a key role in the intestinal uptake of calcium. CaT1 shows homology (75%
amino acid sequence identity) to the apical calcium channel ECaC recently cloned from …
intracellular second messenger. Postnatally, all bodily calcium must be absorbed from the
diet through the intestine. Here we report the properties of a calcium transport protein (CaT1)
cloned from rat duodenum using an expression cloning strategy in Xenopus laevis oocytes,
which likely plays a key role in the intestinal uptake of calcium. CaT1 shows homology (75%
amino acid sequence identity) to the apical calcium channel ECaC recently cloned from …