[HTML][HTML] FGF23 as a calciotropic hormone
ME Rodríguez-Ortiz, M Rodríguez - F1000Research, 2015 - ncbi.nlm.nih.gov
ME Rodríguez-Ortiz, M Rodríguez
F1000Research, 2015•ncbi.nlm.nih.govMaintaining mineral metabolism requires several organs and hormones. Fibroblast growth
factor 23 (FGF23) is a phosphatonin produced by bone cells that reduces renal production of
calcitriol–1, 25 (OH) 2 D 3–and induces phosphaturia. The consequences of a reduction in
1, 25 (OH) 2 D 3 involve changes in calcium homeostasis. There are several factors that
regulate FGF23: phosphorus, vitamin D, and parathyroid hormone (PTH). More recently,
several studies have demonstrated that calcium also modulates FGF23 production. In a …
factor 23 (FGF23) is a phosphatonin produced by bone cells that reduces renal production of
calcitriol–1, 25 (OH) 2 D 3–and induces phosphaturia. The consequences of a reduction in
1, 25 (OH) 2 D 3 involve changes in calcium homeostasis. There are several factors that
regulate FGF23: phosphorus, vitamin D, and parathyroid hormone (PTH). More recently,
several studies have demonstrated that calcium also modulates FGF23 production. In a …
Abstract
Maintaining mineral metabolism requires several organs and hormones. Fibroblast growth factor 23 (FGF23) is a phosphatonin produced by bone cells that reduces renal production of calcitriol–1, 25 (OH) 2 D 3–and induces phosphaturia. The consequences of a reduction in 1, 25 (OH) 2 D 3 involve changes in calcium homeostasis. There are several factors that regulate FGF23: phosphorus, vitamin D, and parathyroid hormone (PTH). More recently, several studies have demonstrated that calcium also modulates FGF23 production. In a situation of calcium deficiency, the presence of 1, 25 (OH) 2 D 3 is necessary to optimize intestinal absorption of calcium, and FGF23 is decreased to avoid a reduction in 1, 25 (OH) 2 D 3 levels.
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