[HTML][HTML] Donor smoking is associated with pulmonary edema, inflammation and epithelial dysfunction in ex vivo human donor lungs
LB Ware, JW Lee, N Wickersham, J Nguyen… - American Journal of …, 2014 - Elsevier
Although recipients of donor lungs from smokers have worse clinical outcomes, the
underlying mechanisms are unknown. We tested the association between donor smoking
and the degree of pulmonary edema (as estimated by lung weight), the rate of alveolar fluid
clearance (AFC; measured by airspace instillation of 5% albumin) and biomarkers of lung
epithelial injury and inflammation (bronchoalveolar lavage [BAL] surfactant protein-D (SP-D)
and IL-8) in ex vivo lungs recovered from 298 organ donors. The extent of pulmonary edema …
underlying mechanisms are unknown. We tested the association between donor smoking
and the degree of pulmonary edema (as estimated by lung weight), the rate of alveolar fluid
clearance (AFC; measured by airspace instillation of 5% albumin) and biomarkers of lung
epithelial injury and inflammation (bronchoalveolar lavage [BAL] surfactant protein-D (SP-D)
and IL-8) in ex vivo lungs recovered from 298 organ donors. The extent of pulmonary edema …