Glycolytic inhibition as a strategy for developing calorie restriction mimetics
DK Ingram, GS Roth - Experimental gerontology, 2011 - Elsevier
Calorie restriction (CR) remains the most robust environmental intervention for altering
aging processes and increasing healthspan and lifespan. Emerging from progress made in
many nonhuman models, current research has expanded to formal, controlled human
studies of CR. Since long-term CR requires a major commitment of will power and long-term
negative consequences remain to be determined, the concept of a calorie restriction mimetic
(CRM) has become a new area of investigation within gerontology. We have proposed that a …
aging processes and increasing healthspan and lifespan. Emerging from progress made in
many nonhuman models, current research has expanded to formal, controlled human
studies of CR. Since long-term CR requires a major commitment of will power and long-term
negative consequences remain to be determined, the concept of a calorie restriction mimetic
(CRM) has become a new area of investigation within gerontology. We have proposed that a …
