[HTML][HTML] Manipulation of glucose and hydroperoxide metabolism to improve radiation response
JM Floberg, JK Schwarz - Seminars in radiation oncology, 2019 - Elsevier
Dysregulated glucose and redox metabolism are near universal features of cancers. They
therefore represent potential selectively toxic metabolic targets. This review outlines the
preclinical and clinical data for targeting glucose and hydroperoxide metabolism in cancer,
with a focus on drug strategies that have the most available evidence. In particular, inhibition
of glycolysis using 2-deoxyglucose, and inhibition of redox metabolism using the glutathione
pathway inhibitor buthionine sulfoximine and the thioredoxin pathway inhibitor auranofin …
therefore represent potential selectively toxic metabolic targets. This review outlines the
preclinical and clinical data for targeting glucose and hydroperoxide metabolism in cancer,
with a focus on drug strategies that have the most available evidence. In particular, inhibition
of glycolysis using 2-deoxyglucose, and inhibition of redox metabolism using the glutathione
pathway inhibitor buthionine sulfoximine and the thioredoxin pathway inhibitor auranofin …
