Inhibition of Na+-K+-2Cl-Cotransporter-1 attenuates traumatic brain injury-induced neuronal apoptosis via regulation of Erk signaling
H Hui, W Rao, L Zhang, Z Xie, C Peng, N Su… - Neurochemistry …, 2016 - Elsevier
Traumatic brain injury (TBI) is the leading cause of mortality and morbidity worldwide and is
characterized by immediate brain damage and secondary injuries, such as brain edema and
ischemia. However, the exact pathological mechanisms that comprise these associated
secondary injuries have not been fully elucidated. This study aimed to investigate the role of
the Na+-K+-2Cl-cotransporter-1 (NKCC1) in the disruption of ion homeostasis and neuronal
apoptosis in TBI. Using a traumatic neuron injury (TNI) model inávitro and a controlled cortex …
characterized by immediate brain damage and secondary injuries, such as brain edema and
ischemia. However, the exact pathological mechanisms that comprise these associated
secondary injuries have not been fully elucidated. This study aimed to investigate the role of
the Na+-K+-2Cl-cotransporter-1 (NKCC1) in the disruption of ion homeostasis and neuronal
apoptosis in TBI. Using a traumatic neuron injury (TNI) model inávitro and a controlled cortex …