Traumatic brain injury (TBI) is a major cause of death and disability in the United States and
causes mitochondrial damage leading to impaired brain function. The purpose of this review
is to (1) describe TBI processes and manifestations,(2) examine the mitochondrial
alterations after TBI, specifically increased reactive oxygen species production, decreased
bioenergetics and apoptosis and (3) current TBI treatments. There are various degrees of
severity of TBI, yet all affect mitochondrial function. Currently, health care professionals use …