A role for eosinophils in transplant rejection
Trends in immunology, 2001•cell.com
Eosinophils release inflammatory mediators and cationic proteins that are instrumental in
the pathogenesis of allergic diseases such as bronchial asthma. Here, we review
experimental observations indicating that eosinophils are also involved in the rejection of
allografts. We propose that their role as effectors of transplant damage becomes crucial
when classical pathways of rejection are inhibited and T helper 2 (Th2) cells dominate the
alloimmune response.
the pathogenesis of allergic diseases such as bronchial asthma. Here, we review
experimental observations indicating that eosinophils are also involved in the rejection of
allografts. We propose that their role as effectors of transplant damage becomes crucial
when classical pathways of rejection are inhibited and T helper 2 (Th2) cells dominate the
alloimmune response.
Abstract
Eosinophils release inflammatory mediators and cationic proteins that are instrumental in the pathogenesis of allergic diseases such as bronchial asthma. Here, we review experimental observations indicating that eosinophils are also involved in the rejection of allografts. We propose that their role as effectors of transplant damage becomes crucial when classical pathways of rejection are inhibited and T helper 2 (Th2) cells dominate the alloimmune response.
cell.com