High macrophage PD-L1 expression not responsible for T cell suppression
N Goldman, YD Lomakova, J Londregan, A Bucknum… - Cellular …, 2018 - Elsevier
Tumors are often comprised of microenvironments (TMEs) with a high proportion of cells and
molecules that regulate immunity. Peritoneal cavity (PerC) cell culture reproduces key
features of TMEs as lymphocyte proliferation is suppressed by PerC macrophages (Mϕs).
We monitored the expression of T cell stimulatory (Class II MHC, B7) and inhibitory (PD-L1)
molecules by PerC APCs before and after culture and report here that IFNγ-driven PD-L1
expression increased markedly on PerC Mϕs after TCR ligation, even more so than seen …
molecules that regulate immunity. Peritoneal cavity (PerC) cell culture reproduces key
features of TMEs as lymphocyte proliferation is suppressed by PerC macrophages (Mϕs).
We monitored the expression of T cell stimulatory (Class II MHC, B7) and inhibitory (PD-L1)
molecules by PerC APCs before and after culture and report here that IFNγ-driven PD-L1
expression increased markedly on PerC Mϕs after TCR ligation, even more so than seen …