[HTML][HTML] PD-1 expression on CD8+ T cells regulates their differentiation within lung allografts and is critical for tolerance induction

T Takahashi, HM Hsiao, S Tanaka, W Li… - American Journal of …, 2018 - Elsevier
Immunological requirements for rejection and tolerance induction differ between various
organs. While memory CD8+ T cells are considered a barrier to immunosuppression-
mediated acceptance of most tissues and organs, tolerance induction after lung
transplantation is critically dependent on central memory CD8+ T lymphocytes. Here we
demonstrate that costimulation blockade-mediated tolerance after lung transplantation is
dependent on programmed cell death 1 (PD-1) expression on CD8+ T cells. In the absence …