Survivin expression in colorectal carcinomas: correlations with clinicopathological parameters and survival
JG Kalliakmanis, C Kouvidou, C Latoufis… - Digestive diseases and …, 2010 - Springer
JG Kalliakmanis, C Kouvidou, C Latoufis, G Kouvatseas, D Anagnostakis…
Digestive diseases and sciences, 2010•SpringerBackground Survivin is a new member of the Inhibitor of apoptosis protein family that has a
dual function as a mitotic regulator and apoptosis inhibitor. Survivin is prominently
expressed in transformed cell lines and in many human cancers, including colorectal
carcinoma. The aim of this study is to investigate the expression of survivin in colorectal
carcinomas and its possible associations with clinicopathological parameters and patient
survival. Materials and Methods Sections of formalin-fixed paraffin-embedded tissues from …
dual function as a mitotic regulator and apoptosis inhibitor. Survivin is prominently
expressed in transformed cell lines and in many human cancers, including colorectal
carcinoma. The aim of this study is to investigate the expression of survivin in colorectal
carcinomas and its possible associations with clinicopathological parameters and patient
survival. Materials and Methods Sections of formalin-fixed paraffin-embedded tissues from …
Background
Survivin is a new member of the Inhibitor of apoptosis protein family that has a dual function as a mitotic regulator and apoptosis inhibitor. Survivin is prominently expressed in transformed cell lines and in many human cancers, including colorectal carcinoma. The aim of this study is to investigate the expression of survivin in colorectal carcinomas and its possible associations with clinicopathological parameters and patient survival.
Materials and Methods
Sections of formalin-fixed paraffin-embedded tissues from 77 colorectal carcinomas were immunohistochemistry stained for survivin.
Results
Survivin was mainly detected in the bottom of the glands of normal mucosa with mainly cytoplasmic localization. No survivin expression was found in infiltrating lymphocytes, fibroblasts, smooth muscle cells or neural tissue. Survivin staining was detected in 68/77 (88.3%) colorectal carcinomas. Survivin expression was found to be significantly associated with tumor differentiation (P = 0.02) but not with gender, age or Dukes stage. Survival did not differ according to survivin expression.
Conclusion
Survivin was found in the majority of colorectal carcinomas, suggesting that its expression is an early event in colorectal carcinogenesis. Its expression is statistically significantly associated with tumor differentiation but not with patient survival.
Springer