[HTML][HTML] Comparison of skeletal muscle pathology and motor function of dystrophin and utrophin deficient mouse strains
M van Putten, D Kumar, M Hulsker… - Neuromuscular …, 2012 - Elsevier
The genetic defect of mdx mice resembles that of Duchenne muscular dystrophy, although
their functional performance and life expectancy is nearly normal. By contrast, mice lacking
utrophin and dystrophin (mdx/utrn−/−) are severely affected and die prematurely. Mice with
one utrophin allele (mdx/utrn+/−) are more severely affected than mdx mice, but outlive
mdx/utrn−/− mice. We subjected mdx/utrn+/+,+/−,−/− and wild type males to a 12week
functional test regime of four different functional tests. Mdx/utrn+/+ and+/− mice completed …
their functional performance and life expectancy is nearly normal. By contrast, mice lacking
utrophin and dystrophin (mdx/utrn−/−) are severely affected and die prematurely. Mice with
one utrophin allele (mdx/utrn+/−) are more severely affected than mdx mice, but outlive
mdx/utrn−/− mice. We subjected mdx/utrn+/+,+/−,−/− and wild type males to a 12week
functional test regime of four different functional tests. Mdx/utrn+/+ and+/− mice completed …