Utrophin may be a precursor of dystrophin during skeletal muscle development
S Lin, JM Burgunder - Developmental Brain Research, 2000 - Elsevier
Expression patterns of utrophin were investigated and compared to those of dystrophin and
associated proteins in skeletal muscle of rat embryos from E12 to E21 by
immunohistochemistry. Utrophin was readily detected from E12 on, earlier than full-length
dystrophin on E14. A shorter dystrophin isoform was observed from E12 to E16. The level of
utrophin reached a maximum on E16–17 and then declined while that of dystrophin
increased after E17. A complementary distribution of these two molecules was observed on …
associated proteins in skeletal muscle of rat embryos from E12 to E21 by
immunohistochemistry. Utrophin was readily detected from E12 on, earlier than full-length
dystrophin on E14. A shorter dystrophin isoform was observed from E12 to E16. The level of
utrophin reached a maximum on E16–17 and then declined while that of dystrophin
increased after E17. A complementary distribution of these two molecules was observed on …
